Excellent twitter breakdown from David Sinclair, PhD:
https://twitter.com/davidasinclair/status/125991292869585715....
Some key points:
- The result is so literally incredible that even the first author, Prof. Steve Horvath, didn't believe it at first. I suggested he check if the rats were mixed up, but he assured me he checked their genomes. The rats weren't mixed up and the data is the data.
- Accumulation of fat in old tissues was greatly reduced. All health-related blood biomarkers they assessed (lipids, liver function, blood cells) "were altered towards the values of young rats, without exception."
- Level of oxidative stress, and (wait for it) senescent cells were reduced "by a very considerable degree". Presumably, the immune system cleared the senescent cells. This is what the field is looking for.
