I agree. I'm simply pointing out the fact that with the picture as complex as we know it is I have a knee jerk reaction to people going from "how to have normal BF%" to "ok, let's talk about insulin". It's the same thing with people talking about brain, attention span and productivity. 10 seconds into the discussions it's "dopamine, dopamine ... DOPAMINE"
> So in the case of adipose tissue, it does require glucose in order to store fat. The glycerol backbone for intracellular triglyceride synthesis is provided by glucose.
Yes. And? Glucose to some extent is always present in the blood. Drop the glucose low enough and brain will die. One could say that adipose tissue will always figure out how to store fat.
As we go on you reference Fung (and defend him) a fair bit. I'd like to take this opportunity to state the obvious. Jason Fung is a trained and certified nephrologist, book author, popular doctor and so on. He does not hold (to my knowledge) a PhD nor has he published any peer-reviewed studies.
Thus calling him a quack on my part was bad (I was pulling your leg a bit) but he cannot be considered a scientist either. He's an expert in his field but his books can't be considered textbooks on human endocrinolongy. He's allowed to have his own opinion but asking anybody to agree or disagree with his views without in-depth study of them is asking too much and he haven't (to my knowledge) presented them in the form of some kind of scientific paper it's not worth arguing whether he's right or not.
That being said - the link you provided on FFA is about cholesterol. I fail to see how that's relevant to discussion about FFA impact on insulin resistance?
Alas, to make my point. Obesity is certainly a multifaceted problem. Thermodynamics certainly matter, human psyche, inflammation, hormones - essentially all of that has its place. Looking from a systems point of view there's no reason (and probably there isn't one) to look for single causative agent though some certainly play a grater role.
In my experience both time-restricted feeding, caloric restriction and macro restriction work and have their place depending on the individual. Generally as a rule IF and low-carb are certainly good ideas, I'm not a fan of keto for everything.
