I've definitely noticed mental fatigue from the changed aural environment in my house. I normally work from home, but now that my wife is also WFH, I've realized that hearing her on zoom at the same time as I'm in a meeting (or trying to concentrate) just melts my brain. Can't actually comment on zoom sound quality as have a pair of headphones that doesn't drive me completely nuts, and didn't notice anything about it in the previous few years of WFH...