Yes but these companies also largely exist because you have a deregulated market whereas the European Union is a much more regulated market.
These regulations provide for worker rights, productions and consumption safety, product quality and much more. Something America is lacking in completely.
You also have a government and department of defense that helps a lot of your big multinationals grow and kill it's foreign competitors.
You can look at the acquisition of Alstom by General Eletric as a good example.