> gRPC encoded data is actually not tightly coupled to HTTP/2 frames.
The headers frame, and the capability to have headers before AND after content is a requirement. gRPC requires trailing headers for the status code of the call. Trailing headers frame is a new concept in HTTP/2.
gRPC-Web supports HTTP/1.1 and browsers. It is able to do that by encoding the status into the end of the response body. However gRPC-Web is a different spec.
If HTTP/3+QUIC supports the same features of HTTP/2 then gRPC should work on it. There might be a HTTP/3 specific spec for details around the management of a HTTP/3 connection, but gRPC headers, message content, and proto contracts shouldn't need to change. Take what I say with a grain of salt because I haven't looked closely at HTTP/3+QUIC yet.