https://aws.amazon.com/solutions/limit-monitor/
It starts having issues when you get to 5,000+ ec2 instances, but it's somewhat understandable that they don't aim to support that level of usage within a single AWS account.
On another bullet point: if you go serverless (API/HTTP Gateway, Lambda, Dynamo DB), you automatically get full region DR. I personally recommend HTTP Gateway if you can swing it, API gateway is only worth of it you are doing personal projects (mostly free tier) or are seriously leveraging the API gateway specific features