It means you access your object through a GUID. Think about it like parking your own car vs. a valet. When you park your own car you need to know the address of the garage you parked in, the floor you were on, and the spot you were in. When you valet park, you hand the attendant a ticket and he brings your car back.
With a standard fileshare, you need to walk the filesystem to retrieve your file - this incurs a ton of metadata overhead. It also means when you've got potentially billions of files in a directory, it can be slooooowww. All the metadata requests also make it very chatty - so doing it over a WAN link tends to be extremely painful if it works at all. Newer versions of SMB and NFS have done a lot to batch the metadata requests but they are still protocols meant to happen at extremely low latency inside a datacenter.