A reasonable question, but I suspect we'd already have some idea if this was the case. There's a lot of artificial light with relatively few, narrow frequencies already in use. I imagine someone, somewhere in some bizarre application would have discovered this as a problem.
Since we only see in three color dimensions, it's hard for us to notice day-to-day, but for instance, some fluorescent bulbs are just 5 spikes in particular frequencies. It looks fairly "white" to us, but it's far from normal light.
(I am interpreting your comment as being fatigued of/damaged by very specific frequencies in a way that it would not be fatigued/damaged for the same amount of energy spread out over a wider range still within the given cone's sensitivity range.)
