The spacing of floating point numbers have any bearing on their values.
To be precise: every integer, positive or negative, with magnitude less than 2^53+1, is exactly represented in double-precision. “Extra values in two’s complement” don’t (and couldn’t possibly) effect this at all, since it is a statement about abstract integers and floating-point numbers, neither of which depends on two’s complement representations.
In particular, -2^52 has a sign field of 1, an exponent field of 1023+52=1075, and an all-zero significand field. This number is exactly -2^52.