People will browse your app from ancient mobile phones. Weird smart TVs. play consoles. Chinese browsers you've never heard of but come bundled with some we-something, they will browse your app from PoS, from a DJI smart RC, from a fridge. And from IE6.

And you know what's the best way to mitigate all that mental load? You just start upfront with a framework that was already battle-tested on all these weird browsers.