In this configuration, if you click "Hint" it will say there are no safe squares. If you click "Debug" you'll see they are both question marks. Therefore, whichever you click on will be safe (with a count of either 1 or 4) and the other is forced into being a mine.
The interesting question (if this were earlier in the game): when in this situation and you get to impose your will on which one is safe, what's the "best" one to pick?