My little finger is much shorter than the rest but moving it a few mm to the left is easier than a large jump to the bottom of the keyboard for me.

For example, I use tmux a lot with ctrl-a.

A small movement of the hand left, jumping my little finger onto control (caps) and using my ring finger on A works really well for me.

Btw the first thing I do on getting a new mac is map the right alt key (or enter key back in the day) to control.

I hate having to press both keys with one hand for Ctrl key combos (ctrl-a being the only exception).