Depends on how many kids, and their ages. Between the ages of ~2-8, they're going to bed much earlier than you, and they won't fall asleep if you're still in the room. Add multiple kids—especially different ages with different bedtime routines—and a single room (or even a suite) can be challenging.
We have a favorite AirBnB listing in one town we visit frequently (to see family that doesn't have space to host us) that has some fragile decorations. When we arrive, we do a quick sweep and put them all up high. We're also up-front with the host that we have small children, so they're free to reject our stay if they'd prefer. So far, it's never been an issue.
