A quick look at the Python stdlib gives shows some of the breakage that would occur:
1) existing uses of .format() would break:
aifc.py: raise Error('marker {0!r} does not exist'.format(id))
2) existing uses of "%" formatting would break:
argparse.py: result = '{%s}' % ','.join(choice_strs)
3) many regular expressions would break:
uuid.py: if re.fullmatch('(?:[0-9a-f][0-9a-f]-){5}[0-9a-f][0-9a-f]', value):
4) existing strings which contain uuids would break:
uuid.py: >>> x = uuid.UUID('{00010203-0405-0607-0809-0a0b0c0d0e0f}')