I was internet acquainted for a time with someone suffering chronic migraines. She said she could not do anything with browsers most of the time and switching her phone to dark mode was a problem because it just flipped the colors for everything.
She spent her time on Twitter because it has a terrific dark mode. She couldn't get other things to work for her.
So people who are very photophobic are apparently not finding adequate accommodation for their needs. I poked around a bit after talking to her and confirmed that her criticisms were valid. The current available options don't work well for trying to surf the internet under such constraints.
I'm not advocating that anyone do anything in particular. I'm just talking about use cases I have a little knowledge of. That's it.