So, while it might be cumbersome, but doable for, let's say, Amazon, it could be a real problem for a new small business. Consider this: as a startup, you always wish you can satisfy all you customers. But you cannot. So you make sacrifices, trying to satisfy the customer base that brings to most money first. You always discriminate, even while US Supreme Court may not be able to see it. And there is no other way.
So what this law really means: there still will be commercial web-sites, that are not accessible for some customers. But they can be sued for it. And while it won't drastically improve lives of many of disabled customers, it will improve lives of some lawyer firms, that can use blind people to sue businesses. This won't happen to everyone, but this is one more additional risk, that every entrepreneur will have to consider
I always tend to support blind/deaf/etc people as much as I can, and I honestly care for them. But I don't feel I must be legally obligated to target my services to anyone. And I think this is a stupid law.