> OTOH the amount of "information" needed to perfectly simulate a cell is probably unbounded. Just a corollary of the fact that we currently don't know how to perfectly simulate reality.

This is a very good point. The 'information' in a cell isn't the base pairs in its DNA, but all the atoms that make up the whole cell. And then each atom encapsulates properties such as position, velocity, charge, van der Waals radius etc.

However this considers atoms with classical mechanics. In a quantum mechanical representation it would be very different again and you can start asking really hairy questions about whether information can be created or destroyed.

It's worth reading the prior literature: Markus Covert has gotten pretty good at predicting quantitative phenotypes using whole cell simulations (with very limited cell representations, basically just feature matrices).

https://www.cell.com/abstract/S0092-8674(12)00776-3

Just back of the envelope estimates if you were to do things like scRNAseq, metabolomics, genomics, etc, on every cell. Infeasible but just as a thought experiment. Most DNA is the same, but not exact, and therein lies the rub (cancer). The point on unbounded though is a good one.