The thing that splitting the keyboard (while keeping it flat) helps with is reducing “ulnar deviation” of the wrist (outward rotation in the plane of the hands). It is also possible to avoid ulnar deviation on a standard keyboard by changing typing style a bit, which is why some people have less problem than others with a single-piece keyboard.
What helps most is not splitting the keyboard per se, but tilting the two sides upward toward the center (the ideal is probably something like a 45° tilt, but even a bit of “tenting” helps significantly).
Having the hands palms-down and close together (as forced by a standard keyboard) ends up causing an unpleasant trade-off between (a) forearms rotated uncomfortably inward about their axis (“wrist pronation”), or (b) elbows swung forward or out to the side to reduce the amount of wrist pronation, in the process causing shoulder and back strain, or causing people to rest their elbows, forearms, wrists, or palms on some surface to compensate for the shoulder strain, and often in the process flexing or extending their wrists.
Wrist flexion or extension is really the worst for any kind of repetitive motion. It dramatically reduces strength and responsiveness of the joints, and can cause severe repetitive strain injuries. You will notice that typical human tools are designed very carefully so they can be used with a mostly straight wrist (or tool-user technique has developed to work around tools which don’t make this obvious).
Tilting the keyboard the right amount front-to-back to match the height of the keyboard relative to the torso can help quite a bit; most keyboards I observe in the wild are tilted incorrectly. You want the plane of the keyboard to be roughly parallel to the plane of the forearm. So on a tall desk, the keyboard should be tilted up at the back. On a low keyboard tray they keyboard should be flat or even tilted slightly down at the back.