I don't have huge hand issues due to ergonomics, but I have experienced some.
I have tried most of what is out there: Kinesis Advantage, Maltron, Kinesis Freestyle, Matias Ergo Pro, Microsoft Sculpt, several Vortex...
Paradoxically, my best experience is with an Apple Magic Keyboard 2 (and I use Linux). I think that's because it's tiny, so I can move my hands and use mostly index and thumb fingers. Plus, actuation force is so light. Yet depth is acceptable. This is not a butterfly switch. A great side effect is tiny latency [1].
I also enjoy using the Magic Trackpad, which now works quite well in Linux. Scrolling using a finger gesture is very ergonomic compared to mouse wheels or even trackballs. At least for me. It promotes position variability.
Of course, these Magic Keyboard scissor switches are much more fragile than any mechanical one. In 4 or 5 years of intense use keys start falling apart. That's my experience with an equivalent keyboard in a MacBook Air. So, shortly, I will try to assemble a split keyboard with more shallow mechanical switches, inspired by the Magic Keyboard experience.
[1] https://danluu.com/keyboard-latency/