For example, Rust puts &T and &mut T at the forefront, which leads to a slightly alien way of handling aliasing- it's all or nothing. This makes some things feel way harder than they are in C, but helps out the optimizer (every pointer is now restrict/noalias).

A different language could emphasize (the equivalent of) &Cell<T>, which allows shared mutability but restricts certain "shape changing" mutations. Most of those C patterns would feel easy again, with a bit less of Rust's non-safety-essential guarantees.