So the guy who has his tabs set to 2 and huge font sizes, that's me, because I am disabled, but it could also be my dad, who is just old and would want a larger font size because its easier on the eyes. But we both would still be able to work with bigger tabs or smaller font, it would just be annoying. But that can be true for every coworker, so I think the disabled persons opinion should not have more weight in such a debate.
Leaving alt tags from images makes them unusable for a screen reader though. That argument carries more weight, because the user would not be inconvenienced, but excluded.
And really, I am not arguing against any form of effort to make something work good for all involved, but rather that it often seems that empathy gets only switched on in people when someone plays a minority card. And that sucks.