> Do you have any historic evidence that it ever worked like this?
It worked on South Africa. My hope is similar sanctions could be put on Israel to force it to end the occupation of Palestine. But in these cases the sanctions are for specific wrongdoings that the State can address. The US sanctions against Venezuela, Iran and previously on Cuba are much broader in scope. The US is essentially saying "we will sanction you until you roll over and die" which is of course completely counter-productive. The mullahs in Iran aren't going to surrender just because the US tells them to.