Minor clarification: UART is “just serial” but when people say “serial” they usually mean RS-232 or RS-422, and these don’t use 0V / 5V like you would for 5V logic. They use anywhere from 3-25V signals, with positive voltages for zeroes and negative voltages for ones. Your PC, if it has a serial port on it, probably sends around +/- 13V (this is typical, IIRC).
So don’t hook up 5V logic parts to a serial interface. If you look at RS-232 interface chips they have integrated charge pumps and external capacitors to generate the Tx voltages from Vcc.