I agree, I use octopi but mainly because it is convenient and not to run it remotely.
I'm thinking of eventually enable remote printing though (just to be able to perform long prints), but I will have some safety measures installed before that. All of the below is probably mandatory for me.
* A webcam that I can watch from wherever I am (mobile and browser). Also with audio so that I can listen in on it. I think it would be possible to have an automatic system to listen (or watch) in on the printer to hear anomalies - but I will not have the energy to pursue that.
* I will be able to shut down the power via internet.
* Perhaps automatically shut down printer and then cut power if internet connectivity is lost - preferably with sms notification.
* A smoke alarm that automatically cuts power (will most likely be software controlled though, so not foolproof)
* A heat activated fire extinguisher (haven't done research on it yet but exists quite a few, popular for caravans etc.).
* Decent printer with good track record (prusa), and all the automatic protections enabled (temperature sensors giving up etc.)
I have not yet decided if the above provides a satisfactory level of assurance that nothing will go wrong. I know that just the webcam will provide immense ease of mind - but that is just me being human.