There are people who click on random ads professionally, and Google has been fighting them for a long time. Whatever equilibrium has been reached is probably stable. The best thing to do is block ads and to do our best to stay off the grid - the only thing that no statistician can work with is the absence of data.
They can absolutely work with the absence of data, because you are still doing other things around the web that generates data. They will see you doing other interactions but not ad requests, and they can figure things out from that.