How about a sane Profile manager? This is something I use heavily on Chrome. The "about:profiles" UI doesn't cut it.
Also when I use Firefox on my non-work Fedora machines (and this is going from Fedora 21 to 29) it seriously chews up memory and CPU. Facebook (yeah, I know) is rendered unusable after about 30 mins. And as other post(s) have pointed out, video playback can be a bit janky. These machines aren't slouches either, i5 ~2.5Ghz 4th or 5th gen, 8GB RAM, SSD, and dedicated graphics cards.
I'd love to switch, but these are things that are deal breakers.