If it was a problem, wouldn't game controllers in general be a problem? There's always the assumption that left things (buttons, joysticks, etc.) are for movement and right things are for actions. Would it be better for a leftie if there were mirrored versions of game controllers?
It also doesn't seem obvious that using one's less dominant hand for movement is optimal. Kind of like playing guitar. As a righty who go my start trying to learn solos, I always felt like the left hand had the harder job.