The us-east-1 outage of S3 in spring of 2017 comes to mind. The AWS status page went down and no one could figure out what was going on because the status page had a hard dependency on us-east-1 S3.

To my knowledge, there has never been a global outage for any AWS service, and I've been using them for a long time.

There was the status page, but S3 being down in us-east-1 didn't effect S3 in ap-southeast-1, etc. The big DynamoDB outage a few years back also was limited to us-east-1