That's a really good question, and - contrary to HN tradition - I'm not even going to pretend I have a complete answer. Some cases are easy, for example a lot of non-tech startups are funded by loans rather than equity exchanges. Other cases are surely harder, but I think clear lines can and should be drawn.
The key IMO is that the company should be paying tax somewhere along the line. Right now VC is a double gift - it provides funds to grow, and the corresponding expenditures magically turn into "losses" that erase future tax. Besides its effect on government revenue, it also gives VC-funded companies an unfair advantage (as though they didn't have enough) over competitors who are being taxed more for having the audacity to grow organically.