My last two jobs the recruiters asked me if I had a degree - this came up AFTER they had decided to interview me and when they were entering me in to the system - the degree was just a field to fill in.
I can't say what impact having a degree has had on my salary, and I can't say how hard it would be to get those first couple of years of work experience without a degree (it didn't matter for my first job, but that was 19 years ago), but in terms of applying for jobs once you have experience, I've not seen it matter outside of a few jobs that inexplicably require "a" degree (of any kind).
Several of my friends in the field don't have a college degree, and they appear to be functioning well, but they are also painfully aware of the lack, which tells me it's a source of some stress, be that actual or just hypothetical.