Imagine taking Newton down in the Replication Crisis Wars!
"The Replication Crisis" has basically involved rather different fields - psychology and human biology/medicine most often. The crisis could be called "human and animal testing crisis" imo.
What we do is search for deviations from Newton's inverse square law. Depending upon the distance over which an experiment is performed, the ISL can be correct to a precision as high as ~10^-10 [1]. In particular, our group works to test whether the inverse-square law (or indeed gravity at all) happens as predicted at distances shorter than 100 microns [2]. It still amazes me that at distances shorter than half the diameter of a human hair, nobody has any idea whether gravity even happens.
Newton's early observations (and Kepler's) have been replicated many times -- there is no risk of a major replication-crisis upheaval there.
[1] https://arxiv.org/abs/hep-ph/0307284 (Figure 4)