It is not as simple as it looks. Some degree of globalization already existed for tens of thousands of years, whether through colonialism, Asia-MiddleEast-Europe trade and many more. Even though there are ups and downs in the cycle of regional/global trade, it has continued to move towards more integration, especially due to technological innovations seen in the past 500 years.
Nations that decide to close down in certain areas, may find themselves in a competitive disadvantage to peers making use of data, economies of scale, technology, labour, etc. This is something we have seen happen in history.