>>These are not issues that your average American cares about.
Why not? I think there are wings of both the major parties that feel that there is an "us vs the big bad corporations". Both sides feel there are inherent flaws with the current economics, but would solve it in very different ways.
Employment and how multinationals run themselves are things many people care about. They just can't agree on how to fix it.
That said, I don't disagree that pissing off a group of megacorps this early in the race seems like it's just begging for powerful enemies. But it also seems like it's possible this becomes a point that many of the primary candidates pick up. In that case, it basically becomes a moot point since there's no candidate for the pro-FAANG lobby to back in the field that will align closer with their goals. And when it the game becomes <Democrat> Vs. Trump, everything changes.