On pipelined requests it's not too bad, you're not supposed to pipeline requests that aren't safe to retry. But pipelining ends up being somewhat rare in practice. Reusing an inactive connection is actually pretty risky, the server may be able to shut it down, your network may have silently dropped the connection already (some NAT timeouts are really short, I've seen cases in real mobile networks where the timeout was under a minute!).

I'm not thrilled with multiplexing in http/2, but the sensible stream closure would be really nice to have. If you see a goaway, you know it it saw your request or not, so you can resend it with a clear concensce.