Well, on that... I will chose Vue for something relatively undemanding just for the sake of convenience, and availability of devs. For something more performance critical, S.js + surplus looks to me the best library around today that provides lightweight data binding, templating and reactivity without feature bloat.
Thank you- I do care a lot about performance. About S.js, wow, that does look amazingly simple- just my type. I went through your comments (sorry if that's not appropriate) and it seemed to me that you're mostly into electronics. But your comment about js seemed well-informed after some other research I did. So thanks a lot, I'm surprised that I never learned this before.