I suspect legalization would have positive effects in the US as well, but I do not suspect it will slow consumption. This is evidenced by juvenile vaping rates. The trends indicate that vaping is on schedule to far exceed historic levels of tobacco consumption by minors. Vaping is generally healthier than tobacco having little or no toxins, but the nicotine content is variable and can occur in far greater concentrations than in tobacco products resulting in greater addiction rates than tobacco. Whether or not nicotine were criminalized demand and consumption would continue to grow. The problem is not legality or even availability. The problem is demand. Children want to smoke nicotine products that taste like candy. The messaging is that tobacco is bad, but vaping is... (not communicated).
I suspect the differences in cultural attitudes between Portugal and the US are a large factor for the differences in evidence of success.