For example, Ignaz Semmelweis (from wiki):
> Despite various publications of results where hand washing reduced mortality to below 1%, Semmelweis's observations conflicted with the established scientific and medical opinions of the time and his ideas were rejected by the medical community. Semmelweis could offer no acceptable scientific explanation for his findings, and some doctors were offended at the suggestion that they should wash their hands and mocked him for it. In 1865, Semmelweis suffered a nervous breakdown and was committed to an asylum, where he died at age 47 of pyaemia
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