Yes and no. You are still at a disadvantaged even if you write a good resume. As an HR, when I need to fill a job, I search my existing database for candidates. I input keywords such as Unity3d, Unreal Engine, UI, etc. If I know another AAA studio has a specific department with those skillset, I input that studio name (disadvantage #1).

Let's say the candidate pool comes back with 30+ results. I will only interview 10 candidates realistically because I have other jobs to fill too. I will rank those candidates by experience and background. People that work at existing AAA studios always goes on top of the pile because I know their chances of filling the job is much higher (disadvantage #2). If there are more than 10 candidates from AAA studios, then too bad for you. Indie game developers goes to the bottom pile unless their skill set matches exactly what I need. Even then, he/ she is an unknown, for the simple reason, they might exaggerate their experience and AAA studios can guarantee the candidates quality.

As an HR, I need to meet quotas. And I have only so many hours to spend per day interviewing candidates. Each candidate takes an hour. Interviewing an indie game developer takes more time because I need to make sure he know his stuff. If I keep on passing indie developers that are not up to par to hiring managers, they will reflect that back to my manager.