One down side to CCL is that it will not run on Intel boxes that don't have the SSE2 instruction set extensions. That isn't a big deal if you're doing a web application on the server of your choice (which will probably have SSE2), but if you want to use CCL on a desktop application that runs on Windows (or Linux), it could be a very big deal. People still use old computers, and I believe some of the newer netbooks don't have SSE2. If you're doing a desktop app, the last thing you want your customer to see is "sorry, you can't run that on this machine".
You can read more about this on clozure.com:
http://trac.clozure.com/ccl/wiki/SystemRequirements
And that points to a list of SSE2-capable (and some non-SSE2-capable) machines:
http://en.wikipedia.org/wiki/SSE2
I bring this up only as a caveat to those thinking about using CCL. I think it is great that it is available as a free Common Lisp implementation. It would be even better, however, if this limitation didn't exist.