From a conference I attended years ago, the key motivator is that request/response networking is pretty much already broken when we get to the moon; once Mars comes into the picture, it'll be even more so. When each TCP packet requires an ACK, and an ACK takes minutes to arrive... things break down a bit.
So, the idea behind IPFS and others (SSB comes to mind, except, yacht-themed) is that it's largely a collection of offline networks, and when the planets align -- quite literally -- those networks will exchange all their new blocks.
It's a neat concept.