- 5 invulnerable couriers per team allow for very constant poking and pushing styles as regeneration items can be ferried back and forth from the base. This favours team fighting deathball oriented strategies where you just have non-stop aggression.

- Very limited hero pool, this further compounds on the earlier issue as many good deathball team fighting heroes are on the available pool but some very common counters to this strategy are not.

Also, humans lack experience in this version of the modified "metagame" or they would likely be able to adapt. This is IMO the biggest hurdle for humans, they haven't really played this version of the game and they probably weren't exactly expecting it, the AI has trained over many "computational years", the humans have a couple of games to catch up.