Most of the situations where I care enough about memory and/or pickling overhead fall into the "take a giant block of binary/string data and process ranges of it in parallel" family, in which case there aren't too many references until the subprocesses get to work. If I had more complex structures of data I'd probably get a little less performance bang for my buck, but even then I suspect it would be much faster than multiprocessing's strategy: pickling and sending data between processes via pipes is many times slower than moving the equivalent amount of data by dirty-writing pages into a forked child.

That's not meant to discount anything y'all are saying, though: refcounts are definitely a very important thing to be mindful of in this situation. A child comment suggests gc.freeze, which can help, but can't entirely save you from thinking about this stuff.

It's also very important to be mindful of what happens with your program at shutdown: if you have a big set of references shared via fork(), and all your children shut down around the same time, your memory usage can shoot up as each child tries to de-refcount all objects in scope. This applies even if each child was only operating on a subset of the references shared to it. If you're processing, say, 1GB of data from the parent in 8 children on a 4 core system (doing M>N(cpu) because e.g. children spend some time writing results out to the FS/network), a near-simultaneous shutdown could allocate 9GB of memory in the very worst case, which can cause OOM or unexpected swapping behavior. Throttled shutdowns using a semaphore or equivalent are the way to go in that case.