Well at minimum we mostly know that alcohol and tobacco are on the higher level on the "harm" spectrum than other illegal drugs.
My takeaway is American drug usage has been shaped by a lot of socio economic factors that do not have human or societal health ramifications. There needs to be a total, science-backed overhaul of drug policy for this reason.
You probably shouldn't trust any information thrown at you without critical thinking (including the first three articles that came across my Google search).