Yeah I think this is the right approach to thinking about these things. Careful consideration of the trade-offs and potential consequences. Rather than the "hey we have a new big weapon against X", let's deploy it everywhere! Maybe I was wrong to think people were suggesting this, but history has examples where humans have made these mistakes. So I think instinct to caution for systems we don't understand and can't easily fix (if we break them), is correct.

If we do it like the way you are saying I think it will work. At least I think that's the best chance we have. And I totally agree we must take these chances. And And I'm totally on board with the net benefit/ number of lives saves calculus, and also that we must go beyond natural selection to better our species.

We'll probably be okay because people as a whole have a diversity of opinions: some enthusiastic want to push forward, others want to move more cautiously. Put it together, hopefully we get the right balance. I guess this trait itself evolved, from hunter-gatherers. Only tribes that had the right mix of people: adventurers who want to explore new territory and cautioners who want to be careful, survive on average, I think. Hooray for careful progress.