if you're a developer, or have a development team, loads of options are even more extensible and versatile. and those options would all come with more flexible deployment, testing and scalability options.

if you're not big in to development, you're reliant on a plethora of plugins, and you need to hope that the dozens of plugins you tie together know how to play nicely together. I'd run in to multiple situations where poorly built plugins for plugins were hacked on and then conflicted with other plugins - everyone pointed the finger at someone else. and then the standard support line from a couple vendors (these were plugins with paid support, btw) - "disable 100% of all your plugins, then enable them one by one to see where the problem is". Sweet.

And when I tell people I inherited a wp site with just shy of 60 plugins, few people actually believe me. "I would never do that! I would never built anything with more than 4 (substitute with various numbers representing experience levels of people) plugins - that's all anyone ever needs!"

When it works well, it works well. When it doesn't, it's a bloody nightmare.