It's as if childhood primes us to think that life is all about figuring out what the heck is going on around us, and as a consequence some of us go into something science-y, but then we reach a certain stage in adulthood where we feel like we have a pretty good rough closed form solution to the problem, and now the journey all of a sudden seems empty and without purpose and we just keep going with the lives 16-year old selves planned out for us, with too much cost sunk to pivot. I almost suspect the end-state of science is not some sort of blissful state where we feel like we understand everything, but an utter dread and feeling of emptiness at no longer having a purpose.