Your example is a different audience. As I pointed out, it depends on your target audience. Not every company wants or even needs to do business with the E.U. in order to be successful. I know that sounds strange to someone in Europe, and I've never been able to make my Austrian friends understand it, but it's true. There are millions of businesses from Australia to Alabama and beyond who don't care about the E.U.
For all its noise and bluster about "500 million customers lost!" the European Union is still less than 7% of the world. I think most businesses would be happy to serve the other 93%.