Such as? Products like Office have undergone significant refactoring to remove reliance on Win32. They have something like over 90% code reuse between Office apps on MacOS, OSX, Android, Win32, and Xaml.
With every release of Windows 10, more and more GDI and Win32 is replaced.
Part of the MinWin project was to extricate Win32 from the kernel and have a true separation.
