There is really nothing surprising about the findings. Also note that the animals' brain tissues were analyzed 24 hours after last administration, so it says little to nothing about permanent effects (which have never been found in other studies, afaik). I really don't get why trivial/unsurprising findings like this raise so high on HN.
(It doesn't mean that we're necessarily wrong though).
> However, the combination of cannabis and caffeine mostly caused synergetic response in the level of the neurotransmitters; this implies that both substances produced their individual effects and did not cancel out the effects of one another. This is also expected since they bind primarily to various receptors. Thus, the resultant relative hyper increase is the cumulative effect of their individual influences.
I wonder if it is a more extreme version of drinking tea? Tea has a calming chemical (Theanine), and caffeine so you end up with more of a mellow energy instead of the hyper energy from coffee.
To be clear, there's evidence elsewhere that caffeine and cannabis can have a negative impact on the developing brain, but the data here don't really go in depth on that.
Cannabis affects the brain.
Using both together affects the brain more than we'd expect.
Probably don't let children[1] use cannabis or caffiene, but certainly protect them from heavy long term use of either.
[1] child is hard to define, but maybe anyone under 21.
Accidentally smoking your coffee and brewing your cannabis will make for a rough day I imagine
Of course, this is anecdotal evidence and could be a coincidence, but I am firmly convinced of the effect.
> I am firmly convinced of the effect
It actually impairs attention and affects short-term memory.
One of the reasons I didn’t use it was that it really impacted my ability to do things like mental arthmetric. I worked in sales in school and I remember being freaked out as it felt like a part of my brain was powered down.
I can normally do most addition/multiplication/approximate averages faster than I can type. The time I ran into this I couldn’t spit out an answer for sales tax or add a few numbers together! :)
I’m curious as to why the effect on me was so different than what you experience!
The THC isn't the problem. All in all I completely agree. Microdosing LSD is also a great thing to do but does get incredibly exhausting after a while.
I don’t know about mice, but for a human, that would be a lot of caffeine.
100mg/kg is ~4–5mg for a mouse.
A small absolute amount, but a very large amount relative to body weight, which is what matters. For a human, that's the equivalent of 70 x 8 oz cups of coffee.
Some definitions include very high rates of use.
It would have to be something like "the person using the substance doesn't feel that the positive effects are worth the negative effects but they still cannot stop using it."
> The levels of G-6-PDH were increased in the brain tissues of all the treated animals (Fig. (Fig.5).5). Caffeine produced quite more significant effects relative to cannabis and the combination of both increased the level of G-6-PDH greatly.
Apparently the subnet I'm on has been blocked for bulk downloading.
Maybe paywalled so I'll emphasize the last sentence of the abstract: "Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet."
