I think WebUSB will enable a lot of cool things, though it will definitely be hard to sandbox.
I want to program an Arduino from a web IDE. I want to control a 3d printer or pen plotter from a web application. I want to store things on a flash drive on my iPhone using a web-based file explorer? This last one sounds strange.
On a tangent, I see application runtimes moving into the browser by default with very few performance-critical applications remaining outside that stack. Photoshop and AAA games might be exceptions. Services like databases and web browsers would not have a need to be in Chrome.
(don't hurt me, I know I'm strange.. ~)